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Alternative Names:

Glycogen synthase kinase-3 alpha; GSK-3 alpha; GSK3A

Application:

WB IHC ICC/IF IP

Reactivity:

Human Mouse Rat

Dilution:

WB 1:500~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200 IP 1:50

	Western blot analysis of GSK3 alpha/ beta phosphorylation expression in 293 cell lysate treated with AP.

Purification:

Affinity-chromatography

Specificity:

Phospho-GSK3 (alpha + beta)(Y216 + Y279) Antibody detects endogenous levels of total Phospho-GSK3 (alpha + beta)(Y216 + Y279)

Immunogen:

A synthesized peptide derived from human Phospho-GSK3 (alpha + beta)(Y216 + Y279)

Description:

GSK3A a proline-directed protein kinase of the GSK family. Implicated in the control of several regulatory proteins including glycogen synthase, Myb, and c-Jun. GSK3 and GSK3 have similar functions. GSK3 phophorylates tau, the principal component of neurofibrillary tangles in Alzheimer disease and is required for maximal production of amyloid plaque peptides by secretase.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

CY6567.pdf