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Alternative Names:

glycogen synthase kinase 3 beta; Glycogen synthase kinase-3 beta; GSK-3 beta; GSK3B; GSK3beta isoform;

Application:

WB IHC ICC/IF FC

Reactivity:

Human Mouse

Dilution:

WB 1:500~1:3000 IHC 1:50~1:200 ICC/IF 1:100~1:500 FC 1:200~1:500

	Western blot analysis of GSK3 beta expression in HEK293 cell lysate.
	Immunohistochemical analysis of paraffin-embedded human colon carcinome, using GSK3 beta Antibody.
	Immunofluorescent analysis of Hela cells, using GSK3 beta Antibody .

Purification:

Affinity-chromatography

Specificity:

GSK3 beta Antibody detects endogenous levels of total GSK3 beta

Immunogen:

A synthesized peptide derived from human GSK3 beta

Description:

Glycogen synthase kinase-3 (GSK3) is a proline-directed serine-threonine kinase that was initially identified as a phosphorylating and inactivating glycogen synthase .GSK3B is involved in energy metabolism, neuronal cell development, and body pattern formation.In skeletal muscle, it contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

CY2434.pdf