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Alternative Names:

ERK-1; ERK1; ERT2; kinase ERK1; MAP kinase 1; MAPK 1; MAPK3; MK03; MNK1; p44-ERK1; P44-ERK1; p44-MAPK;

Application:

WB IP

Reactivity:

Human Mouse Rat

Dilution:

WB 1:500~1:2000 IP 1:50

	Western blot analysis of Phospho-Erk1 (T202/Y204) + Erk2 (T185/Y187) expression in A431 cell lysate treated with EGF.
	Succinate induces aberrant mitochondrial fission in cardiomyocytes through GPR91 signaling
	Succinate induces aberrant mitochondrial fission in cardiomyocytes through GPR91 signaling. -Cell Death & Disease
	Polysaccharides from Nostoc commune Vaucher activate macrophages via NF-κB and AKT/JNK1/2 pathways to suppress colorectal cancer growth in vivo. -Food & Function
	Critical role for non?GAP function of Gαs in RGS1?mediated promotion of melanoma progression through AKT and ERK phosphorylation. -Oncology Reports
	CircDLST promotes the tumorigenesis and metastasis of gastric cancer by sponging miR-502-5p and activating the NRAS/MEK1/ERK1/2 signaling. -Molecular Cancer

Purification:

Affinity-chromatography

Specificity:

Phospho-ERK1 (Y204) + ERK2 (Y187) Antibody detects endogenous levels of total Phospho-ERK1 (Y204) + ERK2 (Y187)

Immunogen:

A synthesized peptide derived from human Phospho-ERK1 (Y204) + ERK2 (Y187)

Description:

Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

CY5277.pdf